Cyclic AMP--an intracellular second messenger for interleukin 1.
نویسندگان
چکیده
منابع مشابه
Cyclic AMP--an intracellular second messenger for interleukin 1.
We demonstrated that interleukin 1 (IL-1), a potent peptide mediator in immune and inflammatory responses, stimulates the synthesis of cAMP in a variety of IL-1-responsive cell targets. We also showed that cAMP analogs and cAMP-inducing agents can replace IL-1 in the induction of interleukin 2 receptors on lymphocytes as well as in phytohemagglutinin-induced murine thymocyte proliferation. By u...
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Adenosine 3':5'-monophosphate, commonly known as cAMP, is a key second messenger in living organisms ranging from Dictyostelium to Homo sapiens. cAMP was first described as a regulator of glycogen breakdown in the liver and is now known to be a second messenger for a wide variety of cellular responses in animals. cAMP is produced from ATP by the action of adenylate cyclase and is hydrolyzed to ...
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The innate immune system functions as the first line of defense against invading bacteria and viruses. In this context, the cGAS/STING [cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase/STING] signaling axis perceives the nonself DNA associated with bacterial and viral infections, as well as the leakage of self DNA by cellular dysfunction and stresses, to elicit the ho...
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Adenosine 3':5'-monophosphate, commonly known as cAMP, is a key second messenger in living organisms ranging from Dictyostelium to Homo sapiens. cAMP was first described as a regulator of glycogen breakdown in the liver and is now known to be a second messenger for a wide variety of cellular responses in animals. cAMP is produced from ATP by the action of adenylate cyclase and is hydrolyzed to ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.21.8201